MULTI-DICIPLINARY ASSESSMENTS

Your treatment will begin with a thorough Integrative multidisciplinary assessment. A team of doctors will work together to review your current medical condition and determine your course of treatment. Our Integrative assessment includes special diagnostics not readily available in most hospitals. The initial assessment will include:

• Diagnostic Imaging
• Diagnostic Physical Examination
• Laboratory exams
• Medical assessmen
• Nutritional assessment
• Psychological assessment
• Dentistry (upon request)

Whole Body HYPERTHERMIA

EFFECTS OF Whole body HYPERTHERMIA IN CANCER CELLS

The idea of using heat to treat cancer has been around for some time, but early attempts to treat cancer with heat had mixed results. And it was hard to maintain the right temperature in the right area while limiting the effects on other parts of the body. Today, the whole body hyperrthermia system allows us to have better control and more precise delivery of heat.  When cells in the body are exposed to higher than normal temperatures, changes take place inside the cells. These changes can make the cells more likely to be affected by orthomolecular cancer treatments.

Hyperthermic Ozonification in tumor cells causes an overexposure of oxygen. This results in over-acidification of the heated cells and a lack of nutrients in the tumor. The cell metabolism is destroyed, resulting in cell death (apoptosis) of the tumor cells.  Under normal conditions, tumor cells are invisible for the immune system. But they change under the influence of heat and UV exposure. They then form “heat shock proteins”, certain proteins which appear on the surface of the degenerated cells. The body’s own immune system detects these proteins as extraneous cells, giving a clear indication for the immune cells to fight the cancer cells. Healthy cells do not form heat shock proteins.  Unlike healthy human cells that love oxygen, Cancer virions and Cancer cells, are anaerobic.

Anaerobic cells cannot live in high oxygen concentrations. Malignant cells have an increased rate of glycolysis which leads to the production of more lactate. With ozone therapy, there is a significant decrease in lactate production, showing that the metabolism is being inhibited Tumor cells have a peroxide intolerance due to insufficient peroxidase and catalase. Ozone is thus able to oxidize the outer lipid layer of malignant cells and destroy them through cell lysis.

The whole body Hyperthermia system is used as a cornerstone of our program and has been proven to have phenomenal synergistic effects with the rest of our treatment approach.

LAETRILE

Laetrile is best known for its ability to prevent metastases.  Powerful and natural anti-tumor agent. Laetrile is a natural agent found in over 1,200 plants, particularly in the seeds of common fruits such as apricots, peaches, plums and apples. It is a diglucoside with a cyanide radical that is highly “bio-accessible.” This means that it penetrates through the cellular membrane, reaching high intra-cellular concentrations easily. This cyanide radical is what preoccupies most scientists, but it has been proven that laetrile is completely non-toxic. Our own experience with thousands of patients gives us complete confidence that there is no danger. The normal cells in our body contain an enzyme called rhodenase, which “neutralizes” the laetrile.  This enzyme prevents the laetrile from releasing cyanide. Laetrile serves as glucose to healthy cells that provide energy when metabolized. Malignant cells do not contain the rhodenase enzyme. In the absence of rhodenase, laetrile is activated and the cyanide radical is released within malignant cells. The end result is tumor destruction. The wonderful thing about laetrile is that it only affects cancerous cells and normal cells are left unharmed.

EFFECTIVENESS OF LAETRILE

Laetrile seems to work on all types of cancers. It is effective in reducing tumor related pain. It also increased survivability of critical patients. It is best known for its ability to prevent metastases.

DOSAGE

The most effective method of Laetrile treatment has been 6 grams, intravenous once a day, usually given for three weeks. Laetrile can also be taken orally, however some bacteria in a person’s intestines can cause small amounts of cyanide to be released. For this reason, it is usually suggested that oral doses be limited to 3 grams per day.  By 1974, Laetrile was being used intravenously at levels of six to nine thousand milligrams daily (6 to 9 grams). Generally, it takes an accumulation of fifty to seventy grams over a period of about a week or ten days before the patient can report tangible improvement.

MEGADOSE VITAMIN C

Vitamin C, also known as ascorbic acid, is a water-soluble vitamin. Unlike most mammals and other animals, humans do not have the ability to make their own vitamin C, therefore, we must obtain vitamin C through our diet.

FUNCTION OF VITAMIN C

Vitamin C is required for the synthesis of collagen, an important structural component of blood vessels, tendons, ligaments, and bone. Vitamin C also plays an important role in the synthesis of the neurotransmitter, norepinephrine. Neurotransmitters are critical to brain function and are known to affect mood.  Vitamin C is required for the synthesis of carnitine, a small molecule that is essential for the transport of fat into cellular organelles called mitochondria, where the fat is converted to energy.  Vitamin C is a highly effective antioxidant. Even in small amounts Vitamin C can protect indispensable molecules in the body, such as proteins, lipids (fats), carbohydrates, and nucleic acids (DNA and RNA), from damage by free radicals and reactive oxygen species that can be generated during normal metabolism as well as through exposure to toxins and pollutants (e.g., cigarette smoke). Vitamin C may also be able to regenerate other antioxidants such as Vitamin E.  A large number of studies have shown that increased consumption of fresh fruits and vegetables is associated with a reduced risk for most types of cancer. A number of case-control studies have investigated the role of Vitamin C in cancer prevention. Most have shown that higher intakes of Vitamin C are associated with decreased incidence of cancers of the mouth, throat and vocal chords, esophagus, stomach, colon-rectum, and lung.  A prospective study that followed 870 men over a period of 25 years found that those who consumed more than 83 mg. of Vitamin C daily had a striking, 64% reduction in lung cancer compared with those who consumed less than 63 mg. per day.  A number of observational studies have found increased dietary Vitamin C intake to be associated with decreased risk of stomach cancer, and laboratory experiments indicate that Vitamin C inhibits the formation of carcinogenic compounds in the stomach.  Studies in the 1970’s and 1980’s conducted by Linus Pauling, Ewan Cameron, and colleagues suggested that  very large doses of Vitamin C (10 grams/day intravenously for ten days followed by at least 10 grams/day orally indefinitely) were helpful in increasing the survival time and improving the quality of life of terminal cancer patients.

Intravenous (IV) administration can result in much higher blood levels of Vitamin C than oral administration, and Vitamin C levels that are toxic to cancer cells in culture can be achieved in humans only with intravenous but not oral administration of Vitamin C.  Dr. Mark Levine and colleagues at NIH have investigated the anticancer mechanism responsible for Vitamin C and reported that it involves production of hydrogen peroxide, which is selectively toxic to cancer cells.

Bioscience uses IV Vitamin C in high amount raging from 40 to 70 grams per day.

RESVERATROL

Resveratrol is classified as a polyphenol because of its chemical structure. Polyphenols make up a huge group of plant compounds that are further broken down into other classifications such as flavonoids, proanthocyanidins, and the like.  In the early ‘90s, after wine was pinpointed as the probable answer to the “French paradox,” researchers realized that the Resveratrol content of wine might be the secret ingredient behind the healthy heart effects attributed to it and the traditional Asian heart medicines containing Polygonnum.  Research began in earnest, and just over a decade later, the accolades are enormous:

“marked antioxidant activity”

“shows great promise for preventing cardiovascular disease”

“remarkable inhibitor”

“chemotherapeutic, little or no toxic effects in healthy cells”

“high efficacy against multiple sites”

Dozens of studies were published in this past year alone. Research has uncovered a diverse range of activities that may make resveratrol one of the most useful agents ever discovered for a wide range of human health problems.  Cancer is, perhaps, the most dynamic area of Resveratrol research. Resveratrol is the first natural medicinal to have solid evidence behind it showing that it blocks or stops many stages of cancer. Resveratrol not only prevents cancer, it’s being used as an additional treatment. The number of studies has exploded in the past three years, with the depth of knowledge about this Polyphenol increasing with each report. Resveratrol is a broad-spectrum agent that stops cancer in many diverse ways, from blocking estrogen and androgens to modulating genes.  Some of the latest information about it shows that Resveratrol causes a unique type of cell death, and kills cancer cells whether they do or do not have the tumor suppressor gene, It also works whether cancer cells are estrogen receptor-positive or negative. In addition to these findings, researchers are beginning to uncover the ability of resveratrol supplements to augment other chemotherapies. For example, vitamin D3 converts to a steroid that inhibits the growth of breast cancer cells. Researchers at the University of Notre Dame have shown that resveratrol increases the effects of vitamin D.

Resveratrol also acts against a component of the Western diet that promotes cancer cell growth: linoleic acid.  Linoleic acid is converted to arachidonic, which is converted to hormone-like substances (such as prostaglandin E2 and leukotriene B4) that can promote inflammatory processes that stimulate cancer cell growth, among other things. It has been demonstrated that the Western diet can cause colon cancer in rodents without any other chemical or factor being necessary. In a study from Japan, Resveratrol in an amount easily obtained by supplementation, inhibited the growth of breast cancer cells, and blocked the growth-promoting effects of linoleic acid from the Western diet.

Resveratrol works against a wide range of cancers, both at the preventive and treatment stages. Its ability to stop cancer is connected to its capability, first, to distinguish a cancer cell from a normal cell. Unlike chemotherapeutic drugs that affect normal as well as cancer cells, Resveratrol does not damage healthy cells. Not only is it not harmful to normal cells, it protects them. Second, Resveratrol is sophisticated in its actions.  It doesn’t just scavenge free radicals, it activates and deactivates critical enzymes and genes, hormones and chemicals.

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MELATONIN

MELATONIN’S ANTI-CANCER MECHANISMS

Melatonin can kill directly many different types of human tumor cells. It is a naturally produced cytotoxin, which can induce tumor cell death (apoptosis). In instances where the tumor has already established itself in the body, melatonin has been shown to inhibit the tumor’s growth rate. Melatonin exhibits natural oncostatic activity and inhibits cancer cell growth. In patients in whom cancer already has become a noticeable physical burden and produces overt symptoms, melatonin has been shown to alleviate numerous cancer symptoms and to inhibit development of new tumor blood vessels (tumor angiogenesis), which in turn inhibits the cancer from spreading further (metastasis). Melatonin can retard tumor metabolism and development by lowering the body temperature; it is a natural inducer of hypothermia. Furthermore, as an inducer of antioxidants  and itself a weak preventive antioxidant, melatonin hinders tumor cells from participating in free radical damage to normal cells and consequently limits oxidative damage to DNA, lipids, amino acids, and proteins. In the unfortunate circumstance in which cancer has already overwhelmed the body’s innate cancer-fighting capabilities, including the anti-cancer activity of naturally produced melatonin (levels of which are reduced in most cancer patients), supplemental melatonin may be beneficial. Melatonin plays a critical role in the host defense system against cancer’s progression by activating the cytokine system, which exerts growth-inhibiting properties, and by stimulating the cytotoxic activity of macrophages and monocytes.  Administration of supplemental melatonin has been shown to be beneficial even in the supportive care of advanced and end-stage cancer patients: it lessens tissue wasting and diminishes weight loss, fatigue, weakness, and depression; enhances immune function; improves wound healing; and improves quality of life and survival rates. Furthermore, melatonin improves common symptoms found in both patients with advanced cancer and those undergoing chemotherapy; it counteracts anemia and lymphocytopenia, stimulates platelet production, enhances appetite, and diminishes cancer pain (including bone pain) through its natural analgesic properties. These are substantial benefits considering that approximately half of all patients diagnosed with cancer die because of poor symptom management.

MELATONIN AND HORMONAL THERAPY

Melatonin levels in cancer patients have been correlated with tumor aggressiveness and progression. A high percentage of women with estrogen-receptor-positive breast cancer have low plasma melatonin levels.  Conversely, melatonin inhibits human breast cancer cell growth and reduces tumor spread and invasiveness in-vitro. Indeed, it has been suggested that melatonin acts as a naturally occurring anti-estrogen on tumor cells, as it down-regulates hormones responsible for the growth of hormone-dependent mammary tumors.  Melatonin differs from the classic anti-estrogens such as tamoxifen in that it does not seem to bind to the estrogen receptor or interfere with the binding of estradiol to its receptor. Moreover, melatonin can increase the therapeutic efficacy of tamoxifen and biological therapies such as IL-2.   How melatonin interferes with estrogen signaling is unknown, though recent studies suggest that it acts through a cyclic adenosine monophosphate (cAMP)-independent signaling pathway. It has been proposed that melatonin suppresses the epidermal growth factor receptor3 and exerts its anti-proliferative effects by inducing differentiation as proposed for melanoma cells.  Regardless of the mechanism, in tumorigenesis studies melatonin reduced the incidence and growth rate of breast tumors and slowed breast cancer development. Furthermore, prolonged oral melatonin administration significantly reduced the development of existing mammary tumors. In a metastatic hormone-refractory prostate cancer patient, oral melatonin (5 mg/day) induced disease stabilization for six weeks.

MELATONIN AND ADVANCED CANCER

Numerous clinical studies by Lissoni and colleagues have shown that melatonin adjuvant therapy favorably influences the course of advanced cancer, leading to an improved quality of life and increased survival. In cancer patients with untreatable advanced solid tumors, melatonin significantly lowered the frequency of catabolic wasting (cachexia), weakness (asthenia), low platelet (thrombocytopenia), and white blood cell counts (lymphocytopenia) compared to patients who received supportive care only. Melatonin improved disease stabilization and increased survival percentages at one and five years. Melatonin deficiencies in advanced cancer patients may be due to altered circadian rhythm (disturbed sleep patterns), cancer-related anorexia-cachexia, and reduced food intake as melatonin is produced by the enterochromaffin cells in the gastrointestinal tract in response to feeding. Melatonin supplementation in turn increases appetite, diminishes tissue wasting, and restores sleep continuity in those with cancer. Administration of melatonin to patients with advanced cancer who have only short expected survival times results in some cases in disease stabilization and improvement of performance status.

MELATONIN SUPPLEMENTATION AND CANCER

Extrapolating the reduced melatonin levels observed in aging humans to the cellular level, one might expect to find less melatonin at the cellular level in tumors compared to normal healthy cells if tumor cells “age” (because of their increased growth rate) more rapidly than normal healthy cells. The potentially lower melatonin levels in tumor cells could possibly be normalized by melatonin supplementation, which in turn would be expected to lead to a negative growth advantage in the tumor micro-environment and therefore inhibit tumor growth. Melatonin levels are depressed in individuals with cancers of different origins during the phase of primary tumor growth, whereas normal melatonin levels may be found when remission occurs.'

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SELENIUM

One of the most effective naturally occurring weapons against cancer is, like most healthy things, something many of us are not getting enough of. The mineral selenium has been shown in multiple studies to be an effective tool in warding off various types of cancer, including breast, esophageal, stomach, prostate, liver and bladder cancers. Not many people get the recommended dose of 200 micrograms a day.  Most Americans only get between 60 and 100 micrograms of selenium daily from dietary sources, according to the Life Extension Foundation’s Disease Prevention and Treatment. That means daily supplements might be worth considering.  Research shows selenium, especially when used in conjunction with vitamin C, vitamin E and beta-carotene, works to block chemical reactions that create free radicals in the body (which can damage DNA and cause degenerative change in cells, leading to cancer).  Selenium also helps stop damaged DNA molecules from reproducing. In other words, selenium acts to prevent tumors from developing. “It contributes towards the death of cancerous and pre-cancer cells. Their death appears to occur before they replicate, thus helping stop cancer before it gets started.

SELENIUM MECHANISMS

There are several possible mechanisms for the protective effect of selenium. Selenium activates an enzyme in the body called gluthathione peroxidase that protects against the formation of free radicals—those loose molecular cannons that can damage DNA. In this situation, selenium may work interchangeably (and in synergy) with vitamin E. Selenium inhibits tumor growth and regulates the natural life span of cells, ensuring that they die when they were suppose to instead of turning “immortal” and hence malignant. Selenium Anti-Cancer Effects Some forms of cancer are the result of free radical oxidation that destroys or damages the part of the DNA that regulates cell multiplication. When that happens, the cells can begin to multiply abnormally, damaging the healthy tissue until your whole body is invaded by these wildly proliferating cells. If you already have cancer, selenium may be useful in slowing its progression. Laboratory studies have shown that selenium can inhibit the growth of breast, cervical, colon, and skin cancer. Selenium is protective against many types of cancers, promotes apoptosis, is a powerful antioxidant, and improves quality of life during aggressive cancer therapies.